Journal
ACS NANO
Volume 14, Issue 1, Pages 1033-1044Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b08550
Keywords
cancer; core-shell structure; magnetic hyperthermia therapy; checkpoint blockade immunotherapy; bilateral tumor model
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Funding
- Shanghai Science and Technology Committee Rising-Star Program [19QA1410100]
- National Natural Science Foundation of China [21835007, 51702349, 51771138]
- Natural Science Foundation of Shanghai [17JC1404700]
- Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures [SKL201704]
- Youth Innovation Promotion Association of the Chinese Academy of Science
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Cancer immunotherapy shows promising potential in future cancer treatment but unfortunately is clinically unsatisfactory due to the low therapeutic efficacy and the possible severe immunotoxicity. Here we show a combined magnetic hyperthermia therapy (MHT) and checkpoint blockade immunotherapy for both primary tumor ablation and mimetic metastatic tumor inhibition. Monodispersed, high-performance superparamagnetic CoFe2O4@MnFe2O4 nanoparticles were synthesized and used for effective MHT-induced thermal ablation of primary tumors. Simultaneously, numerous tumor-associated antigens were produced to promote the maturation and activation of dendritic cells (DCs) and cytotoxic T cells for effective immunotherapy of distant mimetic metastatic tumors in a tumor-bearing mice model. The combined MHT and checkpoint blockade immunotherapy demonstrate the great potentials in the fight against both primary and metastatic tumors.
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