Journal
ACS NANO
Volume 14, Issue 1, Pages 142-152Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b05660
Keywords
magnetophoresis; tumor; magnetic; nanoparticles; penetration
Categories
Funding
- NIH/NIBIB [R21 EB023989]
- NIH/NCI [R01 CA181429]
- NIH/NINDS [T32 NS091006]
- U. of Penn. University Research Foundation Award
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Drug delivery to solid tumors is hindered by hydrostatic and physical barriers that limit the penetration of nanocarriers into tumor tissue. When exploiting the enhanced permeability and retention (EPR) effect for passive targeting of nanocarriers, the increased interstitial fluid pressure and dense extracellular matrix in tumors limits the distribution of the nanocarriers to perivascular regions. Previous strategies have shown that magnetophoresis enhances accumulation and penetration of nanoparticles into solid tumors. However, because magnetic fields fall off rapidly with distance from the magnet, these methods have been limited to use in superficial tumors. To overcome this problem, we have developed a system comprising two oppositely polarized magnets that enables the penetration of magnetic nanocarriers into more deeply seeded tumors. Using this method, we demonstrate a 5-fold increase in the penetration and a 5-fold increase in the accumulation of magnetic nanoparticles within solid tumors compared to EPR.
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