Journal
ACS NANO
Volume 14, Issue 1, Pages 337-346Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b05386
Keywords
payload delivery; titanium dioxide; near-infrared light; Ti3+ defects; AMP-resistant bacteria
Categories
Funding
- National Natural Science Foundation of China [21775016, 21874013]
- Research Funds for the Central Universities [N160502001, N170502003, N170908001, N182410008-1]
- China Postdoctoral Science Foundation [2019M661109]
- Talent Project of Revitalizing Liaoning [XLYC1807165]
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The low penetration depth of UV light in mammalian tissue is the critical limitation for the use of TiO2-based photocatalysis in biomedical applications. In this work, we develop an effective near-infrared (NIR)-active photocatalytic platform that consists of a shell structure of upconversion nanocrystals decorated on a core of Au/dark-TiO2. The heart of this system is the strong photocatalytic activity in the visible region enabled by the gold surface-plasmon resonance on dark TiO2(D-TiO2). Simulation and experiment demonstrate for an optimized Au/D-TiO2 combination a highly enhanced light absorption in the visible range. Using ampicillin sodium (AMP) as model drug, we exemplify the effective use of this principle by demonstrating a MR light-triggered photocatalytic payload release. Importantly, the photocatalytically generated reactive oxygen species can effectively inactivate AMP-resistant bacteria strains, thus maintaining an antibacterial effect even after all drug is released. Overall, we anticipate that the here-introduced NIR-light-active photocatalytic cascade can considerably widen TiO2 -based photocatalysis and its applications into the infrared range.
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