Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 7, Pages 8040-8049Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b22957
Keywords
ureter imaging; near-infrared II fluorescence; aggregation-induced emission; highly bright and stable; ureteral injury
Funding
- National Science Foundation of China [21788102, 81472401, 81772708, 21805002]
- Research Grants Council of Hong Kong [C6009-17G, A-HKUST605/16]
- Innovation and Technology Commission [ITCPD/17-9, ITS/254/17, ITC-CNERC14SC01]
- Science and Technology Plan of Shenzhen [JCYJ20180507183832744, JCYJ20170818113538482]
- Jiangsu Provincial Key Medical Discipline [ZDXKA2016012]
- Natural Science Foundation of Jiangsu Province [BK20190175]
- Science and Technology Project for the Youth of Suzhou [KJXW2018006]
- Ming Wai Lau Center for Reparative Medicine Associate Member Program
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Iatrogenic ureteral injury is a dreaded complication of abdominal and pelvic surgeries, and thus, intraoperative identification of ureters is of paramount importance but lacks efficient methods and probes. Herein, we used near-infrared II (NIR-II, 1000-1700 nm) fluorescence imaging with advantages of higher spatial resolution, deeper tissue penetration, lower light scattering, and less tissue autofluorescence to identify ureters by aggregation-induced emission luminogen dots (AIE dots). The intraoperative ureteral injuries and common ureteral diseases can be visualized timely and precisely. Due to the longer emission wavelength and higher quantum yield of the AIE dots, it largely outperforms the commercial indocyanine green dye in brightness and penetration depth. It was the first time to realize the intraoperative identification of ureters in vivo using NIR-II imaging. Thus, our work provides a new platform for intraoperative monitoring during clinical operation.
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