Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 9, Pages 10142-10155Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c00170
Keywords
Fenton reaction; HPFeS2@C; nanocatalysts; triple-enhanced CDT; synergetic photothermal therapy/starvation therapy/CDT
Funding
- Jiangsu Six Category Outstanding Talent [2012-NY-031, NJ-32]
- Jiangsu Province Science and Technology Support Plan [BE2015367]
- Jiangsu Collaborative Innovation Center of Biomedical Functional Materials
- National and Local Joint Engineering Research Center of Biomedical Functional Materials
- Fundamental Research Funds for the Central Universities of Central South University [2019zzts042]
- Hunan Provincial Innovation Foundation for Postgraduate [CX20190098]
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Specific chemical reactions only happen in the tumor region and produce abundant special chemicals to in situ trigger a train of biological and pathological effects that may enable tumor-specific curative effects to treat cancer without causing serious side effects on normal cells or organs. Chemodynamic therapy (CDT) is a rising tactic for cancer therapy, which induces cancer cell death via a localized Fenton reaction. However, the tumor therapeutic effect is limited by the efficiency of the chemical reaction and relies heavily on the catalyst. Here, we constructed hollow porous carbon coated FeS2(HPFeS2@C)-based nanocatalysts for triple-enhanced CDT. Tannic acid was encapsulated in HPFeS2@C for reducing Fe3+ to Fe2+, which had a better catalytic activity to accelerate the Fenton reaction. Afterward, glucose oxidase (GOx) in nanocatalysts could consume glucose in the tumor microenvironment and in situ synchronously produce H2O2, which could improve Fenton reaction efficiency. Meanwhile, the consumption of glucose could lead to the starvation therapy. The photothermal effects of HPFeS2@C could generate heat, which further sped up the Fenton process and implemented synergetic photothermal therapy/starvation therapy/CDT. The biodistribution of nanoparticles was investigated by multimodal magnetic resonance, ultrasound, and photoacoustic imaging. These nanocatalysts could trigger the catalytic Fenton reaction at a high degree, which might provide a good paradigm for nanocatalytic tumor therapy.
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