Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 9, Pages 10183-10192Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c00705
Keywords
nanoparticles; fluorescent probe; hydrothermal synthesis; oligomer; multicolor
Funding
- University of Illinois at Urbana Champaign
- National Institute of Health, Department of Defense
- Children's Discovery Institute
- American Heart Association [18pre34080003/2018]
- Beckman Institute
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Nanoscale fluorescent probes are of great importance due to their capabilities for imaging on multiscale. Herein, we report the first synthesis of structurally well-defined nanoparticulate oligodots developed for multicolor imaging in vitro and in vivo. These nanoparticles are prepared via condensation and curing reactions where the engineering of the solvent results in the nanoparticles with green (lambda(cm) = 550 nm) and red (lambda(cm) = 650 nm) emission range. Differences found in the photophysical properties have been attributed to variations in oligomeric compositions produced during the synthesis as was corroborated by extensive physicochemical characterizations. Specifically, mass spectroscopy provided a picture of the formed species during the synthesis. The feasibility of the oligodots for multicolor imaging is demonstrated both in vitro and in vivo. The red-emitting oligodot is employed for dynamic whole-body imaging in mice. It is envisioned that oligodots would enable multicolor imaging of various biomarkers in complex diseases such as cancer where numerous molecular and metabolic phenotypes work in concert in their emergence.
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