Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 5, Pages 5520-5530Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b20053
Keywords
radiotherapy (RT); hypoxia-associated resistance; TaOx nanospheres; mild-hyperthermia; triple sensitization
Funding
- National Natural Science Foundation of China [81371559, 81671709, 81601550, 81871371, 81701711, 81701836]
- Guangzhou Municipal Science and Technology Project [201804010106]
- National College Students Innovation and Entrepreneurship Training Program [201812121007]
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Radiotherapy (RT) is one of the most widely used cancer treatments in the clinical setting, while hypoxia-associated resistance often occurs. Herein, a PEGylated TaOx-based oxygen-carrying nanoplatform was constructed for triple sensitizing tumor radiotherapy. The high-Z element based hollow mesoporous TaOx nanospheres were prepared following the in situ growth of ultrasmall CuS nanocrystals and then packaged with O-2-saturated perfluoropentane (PFP). NIR laser-triggered mild hyperthermia would lead to the increase of intratumoral blood flow, together with the release of O-2, the radiotherapeutic efficiency would be enhanced. Alternatively, radiant energy would be deposited inside the tumor by the Ta element, therefore triple sensitization of radiotherapy could be achieved. The in vivo studies showed that the as-prepared nanospheres could achieve almost total inhibition of tumor growth without obvious side effects, which provides new possibilities for multisensitizing tumor radiotherapy.
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