Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 3, Pages 3341-3353Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b16249
Keywords
bead-string-shaped DNA nanowire; DNA tetrahedron; multivalent aptamers; drug loading; targeted drug delivery
Funding
- National Natural Science Foundation of China (NSFC) [21775024]
- Key Project of Natural Science Foundation of Fujian Province [2019J02005]
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Due to high programmability and good biocompatibility, DNA has been recognized as a powerful building block for engineering of sophisticated nanostructures for different purposes. Herein, we present the first example of a bead-string-shaped DNA nanowire (BS-nanow) with long-range structural order for in vivo bioimaging and targeted drug delivery. BS-nanow is assembled from DNA tetrahedron units with precise nanometer-scale spatial control, capable of accommodating chemotherapeutic agents with high payload capacity (1204 binding sites) as well as possessing a 60-fold enhanced binding affinity for target cells. Confocal fluorescence imaging and in vivo experiments on CEM subcutaneous tumor-bearing mice show that specific bioimaging of living cells and even systemic delivery of drugs into internal tumor organs and tissues were accomplished, thereby achieving an efficient inhibition of tumor growth in the xenograft model without systemic toxicity. BS-nanow's show potential in vivo applications in accurate diagnosis and targeted therapy for human cancer.
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