Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 1, Pages 209-216Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b17509
Keywords
nanozyme; catalytic activity; ROS-induced aggregation; organ-targeting; traumatic brain injury
Funding
- National Natural Science Foundation of China [21874154, 21573289, 21673292]
- Fundamental Research Funds for Central Universities [18CX02126A]
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Nanozymes show excellent enzyme activity and robust catalytic properties, but the targeting capability to disease organs is limited because of lack of specificity. Herein, we developed an ultrasmall (similar to 3 nm) organic nanozyme that can gradually aggregate under a reactive oxygen species (ROS)-rich environment via a spontaneous reaction, namely, ROS-induced aggregation. The size of nanozymes is 75 and 100 times higher than the original size under (OH)-O-center dot and H2O2 environments without losing enzyme activity. In vitro experiments confirm that nanozymes prefer to aggregate in mitochondria under ROS-rich conditions. Importantly, the nanozymes show in situ ROS-induced aggregation in the brain, similar to 9 times higher uptake than ordinary nanozymes, indicating their potential for treating ROS-related diseases in the central nervous system.
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