Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 4, Pages 4254-4264Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b18855
Keywords
gold nanoshells; platinum; chemotherapy; photothermal therapy; combined therapy; colorectal cancer
Funding
- Ministry of Science and Technology, Taiwan [MOST 106-2221-E-002-071-MY3]
- National Taiwan University Hospital [UN108-003]
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In the present study, we utilize a poly[2-(N,N-dimethylamino)ethyl methacrylate]-poly(epsilon-caprolactone) (PDMA-PCL) micellar template-based gold nanoshell as a nanocarrier of a platinum-based chemotherapeutic drug, dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt). The gold nanoshells not only function as a drug delivery platform but also provide a remarkable photothermal effect, resulting in synergistically combined chemo-photothermal therapy. With the positively charged outstretched hydrophilic PDMA segments, chloroauric anions are attracted to the PDMA-PCL micellar surface and reduced to gold atoms in situ, forming small seeds that nucleate the subsequent growth of gold nanoshells. The DACHPt-loaded gold nanoshells possess strong absorption in the near-infrared (NIR) region and outstanding photothermal conversion effect; thus, they can promote a temperature increase that is sufficient to ablate tumor cells under NIR laser irradiation at a moderate power density (1 W/cm(2)). Furthermore, by exploiting the synergistic effects of platinum-based chemotherapy and photothermal therapy, the DACHPt-loaded gold nanoshells exhibited a profound inhibition of tumor growth compared to chemotherapy or photothermal therapy alone. Therefore, the platinum(II)-loaded gold nanoshells that we proposed herein may be a potential alternative for efficient curative therapy for colorectal cancer.
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