Journal
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
Volume 31, Issue 4, Pages 595-601Publisher
ELSEVIER
DOI: 10.1016/j.jksus.2018.03.024
Keywords
Pyridazine; Alzheimer; Virtual screening; CNS MPO; Golden Triangle; SAR/SPR
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Virtual screening emerged as an important tool in our quest to access successful CNS medicaments for treating Alzheimer's disease. The computational techniques applied in this screening are central nervous system multiparameter optimization (CNS MPO), golden triangle rule, structure activity/property relationships (SAR/SPR), Drug-likeness properties, and lipophilicity indices. These techniques offer the ability to guide drug design and selection to a quickly identify the compounds from a class of acetylcholinesterase inhibitors being pyridazine derivatives, with desirable drug-like attributes. (C) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
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