Journal
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
Volume 16, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12906-016-1209-7
Keywords
LASAP-C; Herbal prescription; Melanin; Tyrosinase; TRP-1; TRP-2; Zebrafish
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Funding
- Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [HN12C0062]
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Background: In this study, the anti-melanogenesis efficacy of clinically used herbal prescription LASAP-C, which consists of four herbal medicines-Rehmanniae Radix Crudus, Lycii Fructus, Scutellariae Radix, and Angelicae Dahuricae Radix, was investigated. Methods: The chemical profile of LASAP-C was established by conducting ultra-performance liquid chromatography-electrospray ionization-mass spectrometry. Anti-melanogenic efficacy was evaluated by tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 expression in B16F10 melanoma cells. In vivo evaluation was performed by using zebrafish model. Results: Molecular evidences suggested that melanin synthesis was inhibited via the down-regulation of tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 expression in B16F10 melanoma cells treated with LASAP-C. The anti-melanogenesis efficacy was also confirmed in vivo by using the zebrafish model. Conclusion: The results of this study provide strong evidences that LASAP-C can be used as an active component in cosmeceutical products for reducing excess pigmentation in the human skin.
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