Journal
ANTIOXIDANTS
Volume 8, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/antiox8100479
Keywords
cyanidin-3-glucoside; phenolic metabolites; gut microbiota; signaling pathways; intestinal injury
Funding
- National Natural Science Foundation of China [31772819]
- Hunan Provincial Natural Science Foundation for Distinguished Young Scholars [2019JJ30012]
- Double-First-Class Construction Project of Hunan Province [kxk201801004]
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Cyanidin-3-glucoside (C3G) is a well-known natural anthocyanin and possesses antioxidant and anti-inflammatory properties. The catabolism of C3G in the gastrointestinal tract could produce bioactive phenolic metabolites, such as protocatechuic acid, phloroglucinaldehyde, vanillic acid, and ferulic acid, which enhance C3G bioavailability and contribute to both mucosal barrier and microbiota. To get an overview of the function and mechanisms of C3G and its phenolic metabolites, we review the accumulated data of the absorption and catabolism of C3G in the gastrointestine, and attempt to give crosstalk between the phenolic metabolites, gut microbiota, and mucosal innate immune signaling pathways.
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