Journal
BIOMOLECULES
Volume 9, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/biom9120791
Keywords
ion channel trafficking; transient receptor potential channels; TRPV2; TRPV4; phosphatidylinositol signaling; stretch-related channels
Categories
Funding
- European Community [PIOF-GA-2009-237120]
- Universitat Autonoma de Barcelona-Programa Banco de Santander Fellowship
- Spanish Government [MINECO BFU2017-87843-R]
- Generalitat de Catalunya [FI-2013FIB00251]
- Carlos III Health Institute
- European Union European Regional Development Funds [CIBERCV CB16/11/00229]
- Strategic Plan for research and health innovation (PERIS) [SLT006/17/00029]
Ask authors/readers for more resources
Transient receptor potential cation channels are emerging as important physiological and therapeutic targets. Within the vanilloid subfamily, transient receptor potential vanilloid 2 (TRPV2) and 4 (TRPV4) are osmo- and mechanosensors becoming critical determinants in cell structure and activity. However, knowledge is scarce regarding how TRPV2 and TRPV4 are trafficked to the plasma membrane or specific organelles to undergo quality controls through processes such as biosynthesis, anterograde/retrograde trafficking, and recycling. This review lists and reviews a subset of protein-protein interactions from the TRPV2 and TRPV4 interactomes, which is related to trafficking processes such as lipid metabolism, phosphoinositide signaling, vesicle-mediated transport, and synaptic-related exocytosis. Identifying the protein and lipid players involved in trafficking will improve the knowledge on how these stretch-related channels reach specific cellular compartments.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
