Journal
MOLECULAR CATALYSIS
Volume 483, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.mcat.2019.110711
Keywords
Mesocellular foam silica (MCF); Butamben(n-Butyl-p-aminobenzoate); Cascade engineering (one pot synthesis); Heteropolyacids; Kinetics; Green chemistry
Categories
Funding
- University Grants Commission (UGC)
- R. T. Mody Distinguished Professor Endowment
- J. C. Bose National Fellowship of Department of Science and Technology (DST), Govt. of India
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Cascade engineered synthesis of the drug butamben (n-butyl-p-aminobenzoate), a local anaesthetic, which is used for the treatment of chronic pain, is presented here. A new multifunctional heterogeneous catalyst was synthesized, characterized and used for the direct synthesis of n-butyl-p-aminobenzoate by hydrogenation and esterification. A mixture of p-nitrobenzoic acid, n-butanol, hydrogen, acetonitrile as solvent and catalyst was used and hydrogenated in which hydrogenation precedes esterification. A series of aluminum exchanged do-decatungstophosphoric acids (DTP) (Al-x-DTP; x = 0.33-1) (5-20% w/w) supported on mesocellular foam silica (MCF) were prepared. 2% Fe loaded on 15% Al0.66DTP/MCF showed the best activity for one-pot synthesis because the metal and acid sites had proper strength and distribution on MCF. Reaction mechanism and kinetic model were developed. The catalyst 2%Fe-15% Al-0.66 DTP/MCF was found reusable for four catalytic cycles. This work presents an interesting case of reaction engineering using multi-functional catalyst useful in synthesis of a pharmaceutical drug butamben and has potential applications in other areas.
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