Journal
WORLD JOURNAL OF CLINICAL CASES
Volume 7, Issue 19, Pages 2916-2929Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.12998/wjcc.v7.i19.2916
Keywords
Colorectal cancer; Cancer screening; Marker; DNA methylation detection
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Funding
- Changzhou High-Level Medical Talents Training Project [2016ZCLJ002]
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Colorectal cancer (CRC) remains a major contributor to the number of cancer-related deaths that occur annually worldwide. With the development of molecular biology methods, an increasing number of molecular biomarkers have been identified and investigated. CRC is believed to result from an accumulation of epigenetic changes, and detecting aberrant DNA methylation patterns is useful for both the early diagnosis and prognosis of CRC. Numerous studies are focusing on the development of DNA methylation detection methods or DNA methylation panels. Thus, this review will discuss the commonly used techniques and technologies to evaluate DNA methylation, their merits and deficiencies as well as the prospects for new methods.
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