Journal
JOURNAL OF ORTHOPAEDIC TRANSLATION
Volume 22, Issue -, Pages 26-33Publisher
ELSEVIER
DOI: 10.1016/j.jot.2019.09.005
Keywords
Allograft; Artificial material; Autograft; Biomaterial; Long-bone segmental defect reconstruction; Tissue engineering
Categories
Funding
- Shenzhen Science and Technology Innovation Commission [JCYJ20170307173012031, JCYJ20170413162104773]
- National Natural Science Foundation of China [51802340, 81672227, 31870956]
- Science and Technology Planning Project of Guangdong Province [2017A030310318]
- Chinese Academy of Sciences [QYZDB-SSW-JSC030]
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Reconstruction of long-bone segmental defects (LBSDs) has been one of the biggest challenges in orthopaedics. Biomaterials for the reconstruction are required to be strong, osteoinductive, osteoconductive, and allowing for fast angiogenesis, without causing any immune rejection or disease transmission. There are four main types of biomaterials including autograft, allograft, artificial material, and tissue-engineered bone. Remarkable progress has been made in LBSD reconstruction biomaterials in the last ten years. The translational potential of this article: Our aim is to summarize recent developments in the divided four biomaterials utilized in the LBSD reconstruction to provide the clinicians with new information and comprehension from the biomaterial point of view.
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