Journal
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
Volume 11, Issue 11, Pages 957-970Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4251/wjgo.v11.i11.957
Keywords
Non-coding RNAs; Long non-coding RNAs; MicroRNAs; Drug resistance; Multidrug resistance; Gastric cancer
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Funding
- National Natural Science Foundation of China (NSFC) [81070378, 81270561]
- Sichuan Outstanding Youth Fund Project Grant [2015JQ0060]
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Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide. The poorly prognosis and survival of GC are due to diagnose in an advanced, non-curable stage and with a limited response to chemotherapy. The acquisition of drug resistance accounts for the majority of therapy failure of chemotherapy in GC patients. Although the mechanisms of anticancer drug resistance have been broadly studied, the regulation of these mechanisms has not been completely understood. Accumulating evidence has recently highlighted the role of non-coding RNAs (ncRNAs), including long non-coding RNAs and microRNAs, in the development and maintenance of drug resistance due to their regulatory features in specific genes involved in the chemoresistant phenotype of GC. We review the literature on ncRNAs in drug resistance of GC. This review summarizes the current knowledge about the ncRNAs' characteristics, their regulation of the genes involved in chemoresistance and their potential as targeted therapies for personalized treatment in resistant GC.
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