Journal
BIOPOLYMERS
Volume 104, Issue 4, Pages 310-316Publisher
WILEY
DOI: 10.1002/bip.22625
Keywords
macrocyclic peptide; protein-protein interface; rational design; inhibitor
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Funding
- National Institutes of Health [R01GM101279, R01GM103843]
- Tsinghua University
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Protein-protein interactions (PPIs) are critical in numerous biological processes including signaling transduction, function regulations, and disease development. To regulate PPIs has been thought to be challenging due to their highly dynamic and expansive interfacial areas. Nonetheless, successful examples have been reported of targeting PPIs using small molecules, peptides, and proteins. Peptides, especially macrocyclic peptides have proven to be a particularly useful tool to inhibit PPIs for their exquisite potency, stability and selectivity. Herein we review the recent developments of this area of research, focusing on the macrocyclic peptides isolated from natural products, identified from library screening, and rationally designed based on structures, as PPI regulators. (C) 2015 Wiley Periodicals, Inc.
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