Journal
WORLD JOURNAL OF STEM CELLS
Volume 11, Issue 10, Pages 803-816Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4252/wjsc.v11.i10.803
Keywords
Stem cell; Microfluidic technology; Three-dimensional cell culture; High-throughput screening
Categories
Funding
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT (MSIT) [NRF-2017R1C1B2002377, NRF-2016R1A5A1010148, NRF2019R1A2C1003111]
- Technology Innovation Program - Ministry of Trade, Industry & Energy (MOTE, Korea) [10067787]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10067787] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Although the recent advances in stem cell engineering have gained a great deal of attention due to their high potential in clinical research, the applicability of stem cells for preclinical screening in the drug discovery process is still challenging due to difficulties in controlling the stem cell microenvironment and the limited availability of high-throughput systems. Recently, researchers have been actively developing and evaluating three-dimensional (3D) cell culture-based platforms using microfluidic technologies, such as organ-on-a-chip and organoid-on-a-chip platforms, and they have achieved promising breakthroughs in stem cell engineering. In this review, we start with a comprehensive discussion on the importance of microfluidic 3D cell culture techniques in stem cell research and their technical strategies in the field of drug discovery. In a subsequent section, we discuss microfluidic 3D cell culture techniques for high-throughput analysis for use in stem cell research. In addition, some potential and practical applications of organ-on-a-chip or organoid-on-a-chip platforms using stem cells as drug screening and disease models are highlighted.
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