Journal
CELLS
Volume 8, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/cells8111461
Keywords
Inflammatory Bowel Disease (IBD); epithelial-to-mesenchymal transition (EMT); microRNAs
Categories
Funding
- National Research, Development and Innovation Office [GINOP-2.3.2-15-2016-00039]
- European Union
- State of Hungary
- European Social Fund [A2-ELMH-12-0082]
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Increasing evidence suggest the significance of inflammation in the progression of cancer, for example the development of colorectal cancer in Inflammatory Bowel Disease (IBD) patients. Long-lasting inflammation in the gastrointestinal tract causes serious systemic complications and breaks the homeostasis of the intestine, where the altered expression of regulatory genes and miRNAs trigger malignant transformations. Several steps lead from acute inflammation to malignancies: epithelial-to-mesenchymal transition (EMT) and inhibitory microRNAs (miRNAs) are known factors during multistage carcinogenesis and IBD pathogenesis. In this review, we outline the interactions between EMT components and miRNAs that may affect cancer development during IBD.
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