Journal
CELLS
Volume 8, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/cells8111373
Keywords
Nr4a1; Nr4a2; Nr4a3; nuclear hormone receptors; metabolism; fuel utilization; proliferation; apoptosis
Categories
Funding
- American Diabetes Association [1-17-IBS-101]
- Diabetes Action Research and Education Foundation [475]
- Beatson Foundation [2019-003]
- BYU HBLL Student Research Grant
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The Nr4a family of nuclear hormone receptors is composed of three members-Nr4a1/Nur77, Nr4a2/Nurr1 and Nr4a3/Nor1. While currently defined as ligandless, these transcription factors have been shown to regulate varied processes across a host of tissues. Of particular interest, the Nr4a family impinge, in a tissue dependent fashion, on cellular proliferation, apoptosis and fuel utilization. The regulation of these processes occurs through both nuclear and non-genomic pathways. The purpose of this review is to provide a balanced perspective of the tissue specific and Nr4a family member specific, effects on cellular proliferation, apoptosis and fuel utilization.
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