Related references
Note: Only part of the references are listed.Medulloblastoma
Paul A. Northcott et al.
NATURE REVIEWS DISEASE PRIMERS (2019)
Targeting Hedgehog Signalling through the Ubiquitylation Process: The Multiple Roles of the HECT-E3 Ligase Itch
Paola Infante et al.
CELLS (2019)
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP
Francesca Bufalieri et al.
NATURE COMMUNICATIONS (2019)
Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened
Silvia Pietrobono et al.
FRONTIERS IN GENETICS (2019)
Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold
Simone Berardozzi et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61
Andrea Calcaterra et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2018)
Strategies to target the Hedgehog signaling pathway for cancer therapy
Minhang Xin et al.
MEDICINAL RESEARCH REVIEWS (2018)
Itch/beta-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis
Paola Infante et al.
NATURE COMMUNICATIONS (2018)
Current trends in Hedgehog signaling pathway inhibition by small molecules
Francesca Ghirga et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)
Natural Products Inspired Modulators of Cancer Stem Cells-specific Signaling Pathways Notch and Hedgehog
Rocco Palermo et al.
CURRENT PHARMACEUTICAL DESIGN (2018)
Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors
Silvia Pietrobono et al.
CELLS (2018)
Development of anticancer agents targeting the Hedgehog signaling
Xiangqian Zhang et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2017)
Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy
Ekaterina Pak et al.
DEVELOPMENTAL CELL (2016)
In vitro models of medulloblastoma: Choosing the right tool for the job
Delyan P. Ivanov et al.
JOURNAL OF BIOTECHNOLOGY (2016)
Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype
Paola Infante et al.
CELL DEATH & DISEASE (2016)
Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma
Scott X. Atwood et al.
CANCER CELL (2015)
Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma
Hayley J. Sharpe et al.
CANCER CELL (2015)
Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy
Silvia Pandolfi et al.
EXPERT REVIEWS IN MOLECULAR MEDICINE (2015)
Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032
Giles W. Robinson et al.
JOURNAL OF CLINICAL ONCOLOGY (2015)
β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma
Jenny Zinke et al.
MOLECULAR CANCER (2015)
Targeting GLI factors to inhibit the Hedgehog pathway
Paola Infante et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2015)
Non-Canonical Hh Signaling in Cancer-Current Understanding and Future Directions
Dongsheng Gu et al.
CANCERS (2015)
Targeting the Hedgehog Pathway in Pediatric Medulloblastoma
Sherri Y. Huang et al.
CANCERS (2015)
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors
Paola Infante et al.
EMBO JOURNAL (2015)
Isoflavones: Chemistry, Analysis, Functions and Effects on Health and Cancer
Kwang-Pil Ko
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2014)
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition
Yujie Tang et al.
NATURE MEDICINE (2014)
Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy
Fritz Aberger et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2014)
Targeting of Smoothened for therapeutic gain
Martial Ruat et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2014)
Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography
Uwe Weierstall et al.
NATURE COMMUNICATIONS (2014)
Personalizing the Treatment of Pediatric Medulloblastoma: Polo-like Kinase 1 as a Molecular Target in High-Risk Children
Joanna Triscott et al.
CANCER RESEARCH (2013)
PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress
D. Mazza et al.
CELL DEATH AND DIFFERENTIATION (2013)
Neuropilin-2 contributes to tumorigenicity in a mouse model of Hedgehog pathway medulloblastoma
Melanie G. Hayden Gephart et al.
JOURNAL OF NEURO-ONCOLOGY (2013)
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
Dereck Amakye et al.
NATURE MEDICINE (2013)
The mechanisms of Hedgehog signalling and its roles in development and disease
James Briscoe et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples
Paul A. Northcott et al.
ACTA NEUROPATHOLOGICA (2012)
The Crosstalk of mTOR/S6K1 and Hedgehog Pathways
Yan Wang et al.
CANCER CELL (2012)
FRED and HYBRID docking performance on standardized datasets
Mark McGann
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2012)
Vismodegib
Andrzej Dlugosz et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome
Jean Y. Tang et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
The Hedgehog Signal Transduction Network
David J. Robbins et al.
SCIENCE SIGNALING (2012)
Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists
Ciara Metcalfe et al.
CANCER RESEARCH (2011)
FRED Pose Prediction and Virtual Screening Accuracy
Mark McGann
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)
Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal
L. Di Marcotullio et al.
ONCOGENE (2011)
Histone deacetylase and Cullin3-RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation
Gianluca Canettieri et al.
NATURE CELL BIOLOGY (2010)
Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma
Silvia Buonamici et al.
SCIENCE TRANSLATIONAL MEDICINE (2010)
Pediatric medulloblastoma: Toxicity of current treatment and potential role of protontherapy
Piero Fossati et al.
CANCER TREATMENT REVIEWS (2009)
Brief Report: Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449.
Charles M. Rudin et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
Robert L. Yauch et al.
SCIENCE (2009)
Hedgehog: functions and mechanisms
Markku Varjosalo et al.
GENES & DEVELOPMENT (2008)
Medulloblastoma in childhood: new biological advances
John R. Crawford et al.
LANCET NEUROLOGY (2007)
The Gli code: an information nexus regulating cell fate, stemness and cancer
Ariel Ruiz i Altaba et al.
TRENDS IN CELL BIOLOGY (2007)
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch- dependent ubiquitination
Lucia Di Marcotullio et al.
NATURE CELL BIOLOGY (2006)
Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal
T Sheng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Improved protein-ligand docking using GOLD
ML Verdonk et al.
PROTEINS-STRUCTURE FUNCTION AND GENETICS (2003)
Mutations in SUFU predispose to medulloblastoma
MD Taylor et al.
NATURE GENETICS (2002)
The developmental biology of brain tumors
R Wechsler-Reya et al.
ANNUAL REVIEW OF NEUROSCIENCE (2001)