Journal
JOURNAL OF CLINICAL MEDICINE
Volume 8, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/jcm8122051
Keywords
statin; endothelial nitric oxide; angiogenesis; heart failure; atherosclerosis; cancer; neuroprotection
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Funding
- National Institute for Medical Research Development, Tehran, Iran [963401]
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In addition to their cholesterol-lowering effects, statins are associated with pleiotropic effects including improvements in heart failure (HF), reduced blood pressure, prevention of the rupture of atherosclerotic plaques and improved angiogenesis. In addition to these cardiovascular benefits, statins have been implicated in the treatment of neurological injuries, cancer, sepsis, and cirrhosis. These cholesterol-independent beneficial effects of statins are predominantly mediated through signaling pathways leading to increased production and bioavailability of nitric oxide (NO). In this review, the mechanistic pathways and therapeutic effects of statin-mediated elevations of NO are described and discussed.
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