Journal
FRONTIERS IN PEDIATRICS
Volume 7, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fped.2019.00481
Keywords
severe combined immunodeficiency; SCID; clinical presentation; infections; hematopoietic stem cell transplantation; HSCT
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Severe Combined Immunodeficiencies (SCID) are a heterogeneous group of monogenetic diseases. We describe the typical clinical presentation of patients with SCID as well as basic principles in diagnosis and therapy by hematopoietic stem cell transplantation. Therapeutic strategies may differ between subtypes and the inherent reduced capacity or inablility to reject a graft have to be considered.
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