Journal
FRONTIERS IN CHEMISTRY
Volume 7, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2019.00810
Keywords
multicomponent reaction; ketoamide; heterocycles; nitro; dihydropyrroles; cascade reaction; 1,5-dipolar cyclization
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Funding
- National Natural Science Foundation of China [81673296]
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We report a metal-free and stereoselective four-component reaction between alpha-ketoamides, amines, aromatic aldehydes and beta-nitroalkenes or beta-pivaloxy-nitroalkanes to obtain 2,3-dihydro-4-nitropyrroles functionalized in every position. The heterocycles accessible using this reaction may have utility in the synthesis of pharmacologically active compounds.
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