Journal
REDOX BIOLOGY
Volume 29, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.redox.2019.101395
Keywords
beta-Hydroxybutyrate; Redox homeostasis; Stress response molecule; Ischemia and reperfusion
Categories
Funding
- Consejo Nacional de Ciencia y Tecnologia (CONACyT)
- CONACYT-Mexico [A1-S-7495]
- Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica (PAPIIT-Mexico) [IN202219]
- Programa de Apoyo a la Investigacion y Posgrado (PAIP-Mexico) [5000-9105]
- Fondos del Gasto Directo autorizado a la Subdireccion de Investigacion Basica, Instituto Nacional de Cardiologia Ignacio Chavez
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The ketone body beta-hydroxybutyrate is no longer viewed simply as a metabolic intermediate, as it regulates a broad range of physiological processes at cellular and systemic levels. Particularly, beta-hydroxybutyrate functions as a stress response molecule and orchestrates an antioxidant defense program to maintain redox homeostasis in response to environmental and metabolic challenges, such as ischemia. This property of beta-hydroxybutyrate might be key for the beneficial effect of calorie restriction on stress response and disease processes.
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