Journal
FRONTIERS IN IMMUNOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.02532
Keywords
IL-36; autoimmunity; immune cell; inflammation; cytokine
Categories
Funding
- National Natural Science Foundation of China [81701606]
- Sichuan Provincial Science and Technology Program [2019YJ0540]
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Interleukin (IL)-36 is a member of the IL-1 superfamily and includes three agonists (IL-36 alpha, IL-36 beta, and IL-36 gamma) and an antagonist (IL-36Ra). IL-36 agonists bind to heterodimeric receptor complexes. Then, the heterotrimer complexes signal via intracellular functional domains, binding to downstream signaling proteins and inducing inflammatory responses. In this review, we summarized the current knowledge about the biological role of IL-36 and its correlation with systemic inflammatory diseases. The information collected will help to increase the understanding of the potential of IL-36 and may give clues for developing novel therapeutic strategies.
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