Journal
STEM CELL REPORTS
Volume 13, Issue 5, Pages 793-802Publisher
CELL PRESS
DOI: 10.1016/j.stemcr.2019.09.008
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Funding
- Wellcome Trust [108726/Z/15/Z]
- UK Biotechnology and Biological Sciences Research Council [BB/N009061/1]
- BBSRC [BB/N009061/1] Funding Source: UKRI
- Wellcome Trust [108726/Z/15/Z] Funding Source: Wellcome Trust
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Oriens lacunosum-moleculare (O-LM) interneurons constitute 40% of hippocampal interneurons expressing Somatostatin (SST). Recent evidence has indicated a dual origin for these cells in the medial and caudal ganglionic eminences (MGE and CGE), with expression of Htr3a as a distinguishing factor. This is strikingly different from cortical SST interneurons that have a single origin within the MGE/preoptic area (POA). We reassessed the origin of hippocampal SST interneurons using a range of genetic lineage-tracing mice combined with single-cell transcriptomic analysis. We find a common origin for all hippocampal SST interneurons in NKX2-1-expressing progenitors of the telencephalic neuroepithelium and an MGE/POA-like transcriptomic signature for all SST clusters. This suggests that functional heterogeneity within the SST CA1 population cannot be attributed to a differential MGE/CGE genetic origin.
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