Journal
BMB REPORTS
Volume 49, Issue 4, Pages 201-207Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2016.49.4.042
Keywords
CRISPR-Cas system; Crystal structure; Single molecule; Type I CRISPR; Type II CRISPR
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Funding
- Plant Molecular Breeding Center of Next Generation BioGreen 21 Program [PJ01119201]
- Young Faculty supporting fund of Hanyang University
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The CRISPR-Cas system has emerged as a fascinating and important genome editing tool. It is now widely used in biology, biotechnology, and biomedical research in both academic and industrial settings. To improve the specificity and efficiency of Cas nucleases and to extend the applications of these systems for other areas of research, an understanding of their precise working mechanisms is crucial. In this review, we summarize current studies on the molecular structures and dynamic functions of type I and type II Cas nucleases, with a focus on target DNA searching and cleavage processes as revealed by single-molecule observations.
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