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Applications of Carbon Nanotubes in Bone Tissue Regeneration and Engineering: Superiority, Concerns, Current Advancements, and Prospects

Journal

NANOMATERIALS
Volume 9, Issue 10, Pages -

Publisher

MDPI
DOI: 10.3390/nano9101501

Keywords

carbon nanotubes; bone regeneration; tissue engineering; scaffolds; drug system

Funding

  1. National Key R&D Program of China [2017YFC1104703]
  2. National Natural Science Foundation of China [11972065, 31771042]
  3. Fok Ying Tung Education Foundation [141039]
  4. Defence Industrial Technology Development Programme [JCKY2018601B106, JCKY2017205B03]
  5. State Key Laboratory of New Ceramic and Fine Processing Tsinghua University
  6. Key Laboratory of Advanced Materials of Ministry of Education (Tsinghua University)
  7. International Joint Research Center of Aerospace Biotechnology and Medical Engineering, Ministry of Science and Technology of China
  8. 111 Project [B13003]

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With advances in bone tissue regeneration and engineering technology, various biomaterials as artificial bone substitutes have been widely developed and innovated for the treatment of bone defects or diseases. However, there are no available natural and synthetic biomaterials replicating the natural bone structure and properties under physiological conditions. The characteristic properties of carbon nanotubes (CNTs) make them an ideal candidate for developing innovative biomimetic materials in the bone biomedical field. Indeed, CNT-based materials and their composites possess the promising potential to revolutionize the design and integration of bone scaffolds or implants, as well as drug therapeutic systems. This review summarizes the unique physicochemical and biomedical properties of CNTs as structural biomaterials and reinforcing agents for bone repair as well as provides coverage of recent concerns and advancements in CNT-based materials and composites for bone tissue regeneration and engineering. Moreover, this review discusses the research progress in the design and development of novel CNT-based delivery systems in the field of bone tissue engineering.

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