Journal
BLOOD REVIEWS
Volume 30, Issue 4, Pages 263-274Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.blre.2016.01.001
Keywords
Erythrocytes; Inflammation; Electron microscopy; Precision and individualised patient-orientated medicine
Categories
Funding
- National Research Foundation (NRF)
- Medical Research Council (MRC) of South Africa: E Pretorius
Ask authors/readers for more resources
The relevance of erythrocyte light microscopy analysis (a well-known haematological method) is under the spotlight, however there is a place for innovative electron microscopy, (together with biochemical markers) in a pathology laboratory. Inflammation is a key indicator of the health status and erythrocytes are extremely sensitive to oxidative stress or cytoldne upregulation, which typically accompany systemic inflammation in most diseases. They are probably the most adaptable cells, and due to their short lifespan, may form a vital indicator of health, and could play a central part in tracking disease and treatment. As the NIH is proposing a precision medicine approach and because individualised medicine should form an essential part in diagnosis and treatment, biophysical combined with biochemical analysis of erythrocytes may be a novel method to track the inflammatory status before and after treatment. This will allow a fully individualised patient orientated precision medicine approach, where one-medication-regime-fits-all is no longer appropriate. (C) 2016 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available