Journal
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
Volume 8, Issue 13, Pages 1067-1075Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/cer-2019-0062
Keywords
bendamustine; diffuse large B-cell lymphoma; gemcitabine; oxaliplatin; real-world study; rituximab
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Funding
- F Hoffman-La Roche Ltd.
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Aim: Despite long-term responses to first-line immunochemotherapy, many patients with diffuse large B-cell lymphoma (DLBCL) have relapsed/refractory disease. Second-line treatment options are available. However, a large proportion of patients are ineligible for transplantation/intensive therapy. Patients & methods: This observational study of 702 patients in the USA, who used second-line therapies for relapsed/refractory DLBCL, evaluated treatment patterns and overall survival (OS). The study focused on the OS outcome of patients receiving second-line rituximab-bendamustine or rituximab-gemcitabine-oxaliplatin. Results & conclusion: Rituximab-bendamustine and rituximab-gemcitabine-oxaliplatin were received by 4.6 and 1.4% of patients, respectively (N = 42/702). Median and 1-year OS rates were similar between regimens. Many of the 200 different treatment regimens observed in second line were modified versions of National Comprehensive Cancer Network regimens.
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