Journal
CATALYSTS
Volume 9, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/catal9120983
Keywords
heterogeneous catalysis; SBA-15; Hoveyda-Grubbs; Aquamet SiPr; stilbene derivatives; chalcone derivatives; influenza A virus
Categories
Funding
- MIUR (Ministero dell'Istruzione, dell'Universita della Ricerca Italiano), PRIN 2017 project ORIGINALE CHEMIAE in Antiviral Strategy-Origin and Modernization of Multi-Component Chemistry as a Source of Innovative Broad Spectrum Antiviral Strategy [2017BMK8JR_002]
Ask authors/readers for more resources
Stilbene and chalcone derivatives with biological activity against influenza A virus have been synthesized by self-, cross-, and ring-closing metathesis procedures. The reactions were performed under environmentally friendly conditions using the second generation Hoveyda-Grubbs catalyst Aquamet SiPr after immobilization on Santa Barbara Amorphous mesoporous silicate SBA-15. Irrespective from the experimental conditions, the heterogeneous catalyst showed activity and selectivity comparable than the homogeneous counterpart for at least six successive runs without appreciable leaching of the active species. An appreciable antiviral activity against influenza A virus for some of the novel derivatives were observed, mainly involving the early stage of the virus-replication life-cycle.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available