Journal
CANCER MEDICINE
Volume 8, Issue 16, Pages 7032-7043Publisher
WILEY
DOI: 10.1002/cam4.2587
Keywords
apolipoprotein; autophagy; cancer; drug resistance; oxidative stress
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Funding
- Beijing Natural Science Foundation [7172142]
- National Natural Science Foundation of China [81573454]
- Technology Major Projects for Major New Drugs Innovation and Development [2018ZX09711001-005-025]
- CAMS Innovation Fund for Medical Sciences [2016-I2M-3-007]
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The role of apolipoproteins in cardiovascular disease has been well investigated, but their participation in cancer has only been explored in a few published studies which showed a close link with certain kinds of cancer. In this review, we focused on the function of different kinds of apolipoproteins in cancers, autophagy, oxidative stress, and drug resistance. The potential application of apolipoproteins as biomarkers for cancer diagnosis and prognosis was highlighted, together with an investigation of their potential as drug targets for cancer treatment. Many important roles of apolipoproteins and their mechanisms in cancers were reviewed in detail and future perspectives of apolipoprotein research were discussed.
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