Journal
BLOOD
Volume 127, Issue 20, Pages 2406-2410Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2015-08-665547
Keywords
-
Categories
Funding
- Conquer Cancer Foundation/ASCO Career Development Award
- Alex's Lemonade Stand
- St. Baldrick's/Stand Up 2 Cancer
- National Institutes of Health, National Cancer Institute [CA136551-07]
Ask authors/readers for more resources
Administration of lymphodepletion chemotherapy followed by CD19-specific chimeric antigen receptor (CAR)-modified T cells is a remarkably effective approach to treating patients with relapsed and refractory CD19 1 B-cell malignancies. We treated 7 patients with B-cell acute lymphoblastic leukemia (B-ALL) harboring rearrangement of the mixed lineage leukemia (MLL) gene with CD19 CAR-T cells. All patients achieved complete remission (CR) in the bone marrow by flow cytometry after CD19 CAR-T-cell therapy; however, within 1 month of CAR-T-cell infusion, 2 of the patients developed acute myeloid leukemia (AML) that was clonally related to their B-ALL, a novel mechanism of CD19-negative immune escape. These reports have implications for the management of patients with relapsed and refractory MLL-B-ALL who receive CD19 CAR-T-cell therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available