Journal
MEDICAL SCIENCE MONITOR
Volume 25, Issue -, Pages 8172-8180Publisher
INT SCIENTIFIC INFORMATION, INC
DOI: 10.12659/MSM.919872
Keywords
Baicalin; Chinese Traditional Medicine; Mesothelioma; PI3K/AKT/mTOR Signaling Pathway
Categories
Funding
- National Natural Science Foundation of China [31500640, 31670795, 31770849]
- Natural Science Foundation of Zhejiang Province [LY15C070002, LY16C050001, LY15H160048]
- Science Technology Department of Zhejiang Province [2015C33131, 2016F10005]
- Science and Technology Bureau of Jiaxing [2015AY23007]
- Changbai Mountain Scholarship Fund of Jilin Province
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Background: Baicalin, one of the main bioactive components extracted from the traditional Chinese medicine baical Skullcap root, has an anti-tumor activity which had been studied in several cancers. However, its role in human mesothelioma remains unknown. In this study, we investigated the anti-tumor mechanisms of baicalin in the mesothelioma cell line MESO924. Material/Methods: Effects of baicalin on mesothelioma were assessed by measuring cell viability, apoptosis, migration, invasion, inactivation of signaling intermediates, and cell-cycle alterations. Results: Baicalin inhibited the proliferation, migration, and invasion of human mesothelioma cells and increased their apoptosis, all in a dose-dependent manner. Specifically, baicalin decreased the expression of p-EGFR, p-AKT, p-MAPK, p-S6, Bcl-2, and VEGF and increased the expression of Bax in mesothelioma cells. The suppressed mesothelioma cellular proliferation is due to the arrest of the S cell cycle by baicalin. Inhibition of the PI3K/AKT/mTOR signaling pathway by a PI3K/AKT/mTOR inhibitor augmented the anti-proliferation effects induced by baicalin. In addition, baicalin increased the sensitivity of MESO924 to the chemotherapeutic drugs doxorubicin, cisplatin, and pemetrexed. Conclusions: These results highlight the roles of baicalin in inhibiting cell growth, migration, and invasion of mesothelioma cells while increasing apoptosis and sensitizing cells to chemotherapeutic agents through the PI3K/AKT/mTOR signaling pathway, which indicates that baicalin could be a useful drug for mesothelioma therapy.
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