Journal
JOURNAL OF SPORT AND HEALTH SCIENCE
Volume 9, Issue 3, Pages 203-210Publisher
SHANGHAI UNIV SPORT
DOI: 10.1016/j.jshs.2019.10.001
Keywords
Autophagy; Cardiovascular diseases; Exercise
Funding
- National Natural Science Foundation of China [81722008, 91639101, 81570362, 81800358]
- Innovation Program of Shanghai Municipal Education Commission [2017-01-07-00-09-E00042]
- Science and Technology Commission of Shanghai Municipality [17010500100, 18410722200]
- development fund for Shanghai talents
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Cardiovascular disease is the leading cause of human death worldwide. Autophagy is an evolutionarily conserved degradation pathway, which is a highly conserved cellular degradation process in which lysosomes decompose their own organelles and recycle the resulting macro-molecules. Autophagy is critical in maintaining cardiovascular homeostasis and function, and excessive or insufficient autophagy or autophagic flux can lead to cardiovascular disease. Enormous evidence indicates that exercise training plays a beneficial role in the prevention and treatment of cardiovascular diseases. The regulation of autophagy during exercise is a bidirectional process. For cardiovascular disease caused by either insufficient or excessive autophagy, exercise training restores normal autophagy function and delays the progression of cardiovascular disease. An in-depth exploration and discussion of exercise-mediated regulation of autophagy in the cardiovascular system can broaden our view about the prevention of various autophagy-related diseases through exercise training. In this article, we review autophagy and its related signaling pathways, as well as autophagy-dependent beneficial effects of exercise in cardiovascular system. (C) 2020 Published by Elsevier B.V.
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