Journal
BLOOD
Volume 128, Issue 16, Pages 2083-2088Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2016-05-717652
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [26290054, 16K15551]
- National Cancer Center Research and Development Fund [28-A-7]
- Grants-in-Aid for Scientific Research [16K15551, 15H06880, 26290054] Funding Source: KAKEN
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Increasing evidence indicates that the gut microbiota is closely associated with acute graft-versus-host disease (aGVHD) in stem cell transplantation (SCT). Fecal microbiota transplantation (FMT) could represent an alternative treatment option for aGVHD. However, FMT for SCT patients carries a potential risk of infection by infused microbiota because of the severely immunosuppressed status. We therefore conducted a pilot study to evaluate the safety of FMT in SCT. A total of 4 patients with steroid-resistant (n = 3) or steroid-dependent gut aGVHD (n = 1) received FMT. No severe adverse events attributed to FMT were observed. All patients responded to FMT, with 3 complete responses and 1 partial response. Temporal dynamics of microbiota seemed to be linked to the gut condition of patients and peripheral effector regulatory T cells also increased during response to FMT. FMT was safely performed in our patients and might offer a novel therapeutic option for aGVHD. This trial was registered at the University Hospital Medical Information Network (https://upload.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000017575) as #UMIN000015115.
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