Journal
JOURNAL OF NANOBIOTECHNOLOGY
Volume 17, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12951-019-0539-2
Keywords
Platinum-gold nanoraspberries; Photosensitizers; Anticancer photothermal therapy
Funding
- InterDokMed project [POWR.03.02.00-00-I013/16]
- Pik-Instruments
- European Union from the European Regional Development Fund under the Operational Program Innovative Economy, 2007-2013
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BackgroundNew nanophotosensitizers for photothermal cancer therapy (PTT) are still sought. In this paper we propose fancy shaped, non agglomerated core/shell PtAu NRs nanoraspberries (PtAu NRs) as potential nanophotosensitizers in PTT.ResultsLight microscopy images of two colon cancer cell lines (SW480, SW620) showed, that the laser irradiation combined with PtAu NRs caused visible changes in the cell morphology. Fourier Transform InfraRed (FTIR) and Raman spectroscopies showed chemical changes in the DNA, phospholipids, lipids and protein structures caused by laser irradiation in the presence of PtAu NRs. The MTS assay showed similar to 25% mortality of cancer cells due to the addition of PtAu NRs to the cell culture, while for laser irradiation combined with nanoparticles, the mortality of cancer cells increased to 65% for the 650 nm laser and to 60% for the 808 nm laser. The calculated photothermal conversion efficiency reached 62% and 51% for the 650 nm and 808 nm lasers, respectively.ConclusionsPtAu NRs could be applied as effective light-absorbers in the PTT anticancer therapy.
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