Journal
BLOOD
Volume 127, Issue 20, Pages 2427-2438Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2015-11-679639
Keywords
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Funding
- Public Health Service from National Institutes of Health, National Cancer Institute (NCI), National Heart, Lung and Blood Institute (NHLBI) [5U24-CA076518]
- National Institute of Allergy and Infectious Diseases (NIAID) [5U24-CA076518]
- NHLBI [5U10HL069294]
- NCI [5U10HL069294]
- Health Resources and Services Administration (HRSA/DHHS) [HHSH250201200016C]
- Office of Naval Research [N00014-13-1-0039, N00014-14-1-0028]
- Alexion
- Amgen, Inc
- Be the Match Foundation
- Bristol Myers Squibb Oncology
- Celgene Corporation
- Chimerix, Inc
- Fred Hutchinson Cancer Research Center
- Gamida Cell Ltd.
- Genentech, Inc
- Genzyme Corporation
- Gilead Sciences, Inc
- Health Research, Inc
- Roswell Park Cancer Institute
- HistoGenetics, Inc
- Incyte Corporation
- Jazz Pharmaceuticals, Inc
- Jeff Gordon Children's Foundation
- Leukemia & Lymphoma Society
- Medical College of Wisconsin
- Merck Co, Inc
- Mesoblast
- Millennium: The Takeda Oncology Co.
- Miltenyi Biotec, Inc
- National Marrow Donor Program
- Neovii Biotech NA, Inc
- Novartis Pharmaceuticals Corporation
- Onyx Pharmaceuticals
- Optum Healthcare Solutions, Inc
- Otsuka America Pharmaceutical, Inc
- Otsuka Pharmaceutical Co, Ltd.-Japan
- Oxford Immunotec
- Perkin Elmer, Inc
- Pharmacyclics
- Sanofi US
- Seattle Genetics
- Sigma-Tau Pharmaceuticals
- Spectrum Pharmaceuticals, Inc
- St. Baldrick's Foundation
- Sunesis Pharmaceuticals, Inc
- Swedish Orphan Biovitrum, Inc
- Telomere Diagnostics, Inc
- TerumoBCT
- Therakos, Inc
- University of Minnesota
- Wellpoint, Inc.
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Single-center studies have reported an association between early (before day 100) cytomegalovirus (CMV) reactivation and decreased incidence of relapse for acute myeloid leukemia (AML) following allogeneic hematopoietic cell transplantation. To substantiate these preliminary findings, the Center for International Blood and Marrow Transplant Research (CIBMTR) Database was interrogated to analyze the impact of CMV reactivation on hematologic disease relapse in the current era. Data from 9469 patients transplanted with bone marrow or peripheral blood between 2003 and 2010 were analyzed according to 4 disease categories: AML (n=5310); acute lymphoblastic leukemia (ALL, n=1883); chronic myeloid leukemia (CML, n= 1079); and myelodysplastic syndrome (MDS, n= 1197). Median time to initial CMV reactivation was 41 days (range, 1-362 days). CMV reactivation had no preventive effect on hematologic disease relapse irrespective of diagnosis. Moreover, CMV reactivation was associated with higher nonrelapse mortality [relative risk [RR] among disease categories ranged from 1.61 to 1.95 and P values from .0002 to <.0001; 95% confidence interval [CI], 1.14-2.61). As a result, CMV reactivation was associated with lower overall survival for AML (RR=1.27; 95% CI, 1.17-1.38; P <.0001), ALL (RR=1.46; 95% CI, 1.25-1.71; P <.0001), CML (RR=1.49; 95% CI, 1.19-1.88; P =.0005), and MDS (RR = 1.31; 95% CI, 1.09-1.57; P =.003). In conclusion, CMV reactivation continues to remain a risk factor for poor posttransplant outcomes and does not seem to confer protection against hematologic disease relapse.
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