Journal
ELIFE
Volume 8, Issue -, Pages -Publisher
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.48309
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Funding
- National Institute of Allergy and Infectious Diseases [5T32AI100853, 5T32AI007180]
- Deutsches Zentrum fur Infektionsforschung [TI07.001_Rolling]
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Anemia is a common complication of malaria that is characterized by the loss of infected and uninfected erythrocytes. In mouse malaria models, clearance of uninfected erythrocytes is promoted by autoimmune anti-phosphatidylserine (PS) antibodies produced by T-bet(+)beta-cells, which bind to exposed PS in erythrocytes, but the mechanism in patients is still unclear. In Plasmodium falciparum patients with anemia, we show that atypical memory FcRL5(+)T-bet(+) B-cells are expanded and associate both with higher levels of anti-PS antibodies in plasma and with the development of anemia in these patients. No association of anti-PS antibodies or anemia with other B-cell subsets and no association of other antibody specificities with FcRL5(+)T-bet(+) B-cells is observed, revealing high specificity in this response. We also identify FcRL5(+)T-bet(+) B-cells as producers of anti-PS antibodies in ex vivo cultures of naive human peripheral blood mononuclear cells (PBMC) stimulated with P.-falciparum-infected erythrocyte lysates. These data define a crucial role for atypical memory B-cells and anti-PS autoantibodies in human malarial anemia.
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