Journal
ELIFE
Volume 8, Issue -, Pages -Publisher
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.49577
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Funding
- European Molecular Biology Organization [LFT563-2013]
- Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung [P300PA_161002, P2GEP3_148531]
- National Institutes of Health [DP2-GM-119137, R01GM032384]
- National Science Foundation [2016218040, 2012135643, MCB-1146621]
- Howard Hughes Medical Institute [55108535, 826735-0012]
- Swiss National Science Foundation (SNF) [P2GEP3_148531, P300PA_161002] Funding Source: Swiss National Science Foundation (SNF)
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In response to proteotoxic stress, chloroplasts communicate with the nuclear gene expression system through a chloroplast unfolded protein response (cpUPR). We isolated Chlamydomonas reinhardtii mutants that disrupt cpUPR signaling and identified a gene encoding a previously uncharacterized cytoplasmic protein kinase, termed Mars1-for mutant affected in chloroplast-to-nucleus retrograde signaling-as the first known component in cpUPR signal transmission. Lack of cpUPR induction in MARS1 mutant cells impaired their ability to cope with chloroplast stress, including exposure to excessive light. Conversely, transgenic activation of cpUPR signaling conferred an advantage to cells undergoing photooxidative stress. Our results indicate that the cpUPR mitigates chloroplast photodamage and that manipulation of this pathway is a potential avenue for engineering photosynthetic organisms with increased tolerance to chloroplast stress.
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