Journal
CLINICAL EPIGENETICS
Volume 11, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13148-019-0743-9
Keywords
DNA methylation; S5 classifier; Human papillomavirus; Triage; Cervical intraepithelial neoplasia; Cervical cancer
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Funding
- Instituto Nacional de Salud Publica of Mexico
- Coordinacion de Investigacion en Salud del Instituto Mexicano del Seguro Social
- Secretaria de Salud Tlaxcala
- Instituto Nacional de las Mujeres
- Consejo Nacional de Ciencia y Tecnologia
- Cancer Research UK [C569/A10404]
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Background Vigilant management of women with high-risk human papillomavirus (hrHPV) is necessary in cancer screening programs. To this end, we evaluated the performance of S5 (targeting DNA methylation in HPV16, HPV18, HPV31, HPV33, and human gene EPB41L3) to predict cervical intraepithelial neoplasia grade 2 or higher (CIN2+) in a sample of hrHPV-infected women referred to colposcopy in the FRIDA Study, a large screening trial in Mexico. A nested case-control sample with women referred to colposcopy either by atypical squamous cells of undetermined significance or higher (ASCUS+) in cytology and/or positive for HPV types 16 or 18 was tested by S5. Seventy-nine cases of CIN2+ were age-matched to 237 controls without a diagnosis of CIN2+ (
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