Liver-mediated shedding of platelet GPVI

The in vivo mechanisms underlying antibody-based shedding of the key platelet collagen receptor glycoprotein VI (GPVI) are potentially significant for future antibody-based thromboprotective agents. In this issue of Blood, Stegner et al reveal how the inhibitory Fc receptor, Fc gamma RIIB, on mouse liver sinusoidal endothelium mediates both antibody-induced GPVI shedding and entrapment of platelets in the liver.(1)