4.6 Article

Key residues in TLR4-MD2 tetramer formation identified by free energy simulations

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

A Thermodynamic Funnel Drives Bacterial Lipopolysaccharide Transfer in the TLR4 Pathway

Roland G. Huber et al.

STRUCTURE (2018)

Article Chemistry, Medicinal

Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists

Matthew D. Morin et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Review Biochemistry & Molecular Biology

Computational Approaches to Toll-Like Receptor 4 Modulation

Jean-Marc Billod et al.

MOLECULES (2016)

Article Multidisciplinary Sciences

TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS

Ying Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Biochemistry & Molecular Biology

Toll-like receptors: Activation, signalling and transcriptional modulation

Dominic De Nardo

CYTOKINE (2015)

Article Chemistry, Physical

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

James A. Maier et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2015)

Article Biochemistry & Molecular Biology

Dynamics on human Toll-like receptor 4 complexation to MD-2: The coreceptor stabilizing function

Carla de Aguiar et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2015)

Review Cell Biology

TLRs: Linking inflammation and breast cancer

Khyati Bhatelia et al.

CELLULAR SIGNALLING (2014)

Article Chemistry, Medicinal

Toll-like Receptor 4 (TLR4) Modulation by Synthetic and Natural Compounds: An Update

Francesco Peri et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

Review Immunology

Assembly and localization of Toll-like receptor signalling complexes

Nicholas J. Gay et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Article Computer Science, Interdisciplinary Applications

SPFP: Speed without compromise-A mixed precision model for GPU accelerated molecular dynamics simulations

Scott Le Grand et al.

COMPUTER PHYSICS COMMUNICATIONS (2013)

Article Medicine, General & Internal

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis The ACCESS Randomized Trial

Steven M. Opal et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

Article Biochemistry & Molecular Biology

The Structural Basis for Endotoxin-induced Allosteric Regulation of the Toll-like Receptor 4 (TLR4) Innate Immune Receptor

Teresa Paramo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Chemistry, Physical

PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data

Daniel R. Roe et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2013)

Article Chemistry, Physical

MMPBSA.py: An Efficient Program for End-State Free Energy Calculations

Bill R. Miller et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2012)

Review Immunology

Genetic variation in Toll-like receptors and disease susceptibility

Mihai G. Netea et al.

NATURE IMMUNOLOGY (2012)

Review Biochemistry & Molecular Biology

Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies

Amisha Barochia et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2011)

Article Critical Care Medicine

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis

Todd W. Rice et al.

CRITICAL CARE MEDICINE (2010)

Article Multidisciplinary Sciences

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

Beom Seok Park et al.

NATURE (2009)

Review Pharmacology & Pharmacy

Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer

Luke A. J. O'Neill et al.

PHARMACOLOGICAL REVIEWS (2009)

Article Multidisciplinary Sciences

Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4

Thierry Roger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Oncology

Toll-like receptors and cancer

Seth Rakoff-Nahoum et al.

NATURE REVIEWS CANCER (2009)

Review Pharmacology & Pharmacy

Association between the Polymorphisms of TLR4 and CD14 Genes and Alzheimer's Disease

C. R. Balistreri et al.

CURRENT PHARMACEUTICAL DESIGN (2008)

Review Chemistry, Multidisciplinary

GLYCAM06: A generalizable Biomolecular force field. Carbohydrates

Karl N. Kirschner et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

TLR4 signalling in the intestine in health and disease

M. Fukata et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2007)

Article Rheumatology

Amplifying elements of arthritis and joint destruction

Wim B. van den Berg et al.

ANNALS OF THE RHEUMATIC DISEASES (2007)

Article Chemistry, Physical

Implicit nonpolar solvent models

Chunhu Tan et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2007)

Article Biochemistry & Molecular Biology

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist eritoran

Ho Min Kim et al.

Review Cardiac & Cardiovascular Systems

Mechanisms of disease: Toll-like receptors in cardiovascular disease

Stefan Frantz et al.

NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE (2007)

Review Biochemistry & Molecular Biology

Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists

Holger Kanzler et al.

NATURE MEDICINE (2007)

Article Immunology

Opinion - Toll-like receptors as molecular switches

Nicholas J. Gay et al.

NATURE REVIEWS IMMUNOLOGY (2006)

Review Chemistry, Multidisciplinary

The Amber biomolecular simulation programs

DA Case et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2005)

Review Urology & Nephrology

Signaling danger:: Toll-like receptors and their potential roles in kidney disease

HJ Anders et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2004)

Article Immunology

Toll-like receptors in the pathogenesis of human disease

DN Cook et al.

NATURE IMMUNOLOGY (2004)

Article Chemistry, Multidisciplinary

Development and testing of a general amber force field

JM Wang et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Exploring protein native states and large-scale conformational changes with a modified generalized born model

A Onufriev et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2004)

Review Immunology

Toll-like receptors and innate immunity

R Medzhitov

NATURE REVIEWS IMMUNOLOGY (2001)