Journal
OPEN BIOLOGY
Volume 9, Issue 11, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsob.190183
Keywords
model organisms; transcriptional regulation; Caenorhabditis elegans; Drosophila melanogaster
Categories
Funding
- Southern Marine Science and Engineering Guangdong Laboratory Zhanjiang [ZJW-2019-07]
- National Natural Science Foundation of China [81541153]
- Guangdong Provincial Science and Technology Department [2016A050503046, 2015A050502048, 2016B030309002]
- Public Service Platform of South China Sea for R&D Marine Biomedicine Resources [GDMUK201808]
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In this review, we will summarize model organisms used by scientists in the laboratory, including Escherichia coli, yeast, Arabidopsis thaliana, nematodes, Drosophila, zebrafish, mice and other animals. We focus on the progress in research exploring different types of E. coli in the human body, and the specific molecular mechanisms by which they play a role in humans. First, we discuss the specific transcriptional regulation mechanism of E. coli in cell development, maturation, ageing and longevity, as well as tumorigenesis and development. Then, we discuss how the synthesis of some important substances in cells is regulated and how this affects biological behaviour. Understanding and applying these mechanisms, presumably, can greatly improve the quality of people's lives as well as increase their lifespan. For example, some E. coli can activate certain cells by secreting insulin-like growth factor-1, thus activating the inflammatory response of the body, while other E. coli can inactivate the immune response of the body by secreting toxic factors.
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