Journal
CELL REPORTS
Volume 29, Issue 8, Pages 2398-+Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2019.10.067
Keywords
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Categories
Funding
- Brain Recovery Project: Childhood Epilepsy Surgery Foundation
- Della Martin Foundation for Mental Illness
- NSF [BCS-1845958]
- NUS Strategic Research [DPRT/944/09/14]
- NUS SOM Aspiration Fund [R185000271720]
- Singapore NMRC [CBRG/0088/2015]
- NUS YIA
- Singapore National Research Foundation (NRF)
- BRAIN Initiative Cell Census Network [U01MH117023]
- National Institute for Biomedical Imaging and Bioengineering [P41EB015896, 1R01EB023281, R01EB006758, R21EB018907, R01EB019956]
- National Institute on Aging [5R01AG008122, R01AG016495, R56AG064027]
- National Institute for Neurological Disorders and Stroke [R01NS0525851, R21NS072652, R01NS070963, R01NS083534, 5U01NS086625, R01NS105820]
- Caltech Conte Center for the Neurobiology of Social Decision Making [2P50-MH094258]
- Center for Brain Science Neuroinformatics Research Group
- Athinoula A. Martinos Center for Biomedical Imaging
- Center for Human Genetic Research
- [1S10RR023401]
- [1S10RR019307]
- [1S10RR023043]
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A reliable set of functional brain networks is found in healthy people and thought to underlie our cognition, emotion, and behavior. Here, we investigated these networks by quantifying intrinsic functional connectivity in six individuals who had undergone surgical removal of one hemisphere. Hemispherectomy subjects and healthy controls were scanned with identical parameters on the same scanner and compared to a large normative sample (n = 1,482). Surprisingly, hemispherectomy subjects and controls all showed strong and equivalent intrahemispheric connectivity between brain regions typically assigned to the same functional network. Connectivity between parts of different networks, however, was markedly increased for almost all hemispherectomy participants and across all networks. These results support the hypothesis of a shared set of functional networks that underlie cognition and suggest that between-network interactions may characterize functional reorganization in hemispherectomy.
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