Journal
CELL REPORTS
Volume 29, Issue 5, Pages 1192-+Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2019.09.061
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Funding
- National Key Research and Development Program [2016YFD0200305, 2017YFD0200805]
- National Natural Science Foundation of China [31972512, 31501833]
- China Science and Technology Ministry (973 Program) [2015CB150500]
- Fundamental Research Funds for the Central Universities [KJQN201667]
- Innovative Research Team Development Plan of the Ministry of Education of China [IRT_17R56]
- Slovenian Research Agency [P4-0116]
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Bacillus spp. produce a wide range of secondary metabolites, including antibiotics, which have been well studied for their antibacterial properties but less so as signaling molecules. Previous results indicated that the lipopeptide bacillomycin D is a signal that promotes biofilm development of Bacillus velezensis SQR9. However, the mechanism behind this signaling is still unknown. Here, we show that bacillomycin D promotes biofilm development by promoting the acquisition of iron. Bacillomycin D promotes the transcription of the iron ABC transporter FeuABC by binding to its transcription factor, Btr. These actions increase intracellular iron concentration and activate the KinB-Spo0A-SinI-SinR-dependent synthesis of biofilm matrix components. We demonstrate that this strategy is beneficial for biofilm development and competition with the Pseudomonas fluorescens PF-5. Our results unravel an antibiotic-dependent signaling mechanism that links iron acquisition to biofilm development and ecological competition.
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