Journal
CELL REPORTS
Volume 29, Issue 9, Pages 2565-+Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2019.10.107
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Funding
- European Research Council CoG (Cancer-Recurrence) [648804]
- Cancer Genomics Netherlands
- Doctor Josef Steiner Foundation
- European Union's Horizon 2020 research and innovation program under Marie Sklodowska-Curie Actions [642866]
- European Research Council (ERC) [648804] Funding Source: European Research Council (ERC)
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Epithelial-to-mesenchymal transition (EMT) has long been thought to be crucial for metastasis. Recently a study challenged this idea by demonstrating that metastases were seeded by tumor cells that were not marked by an EMT lineage-tracing reporter on the basis of the expression of the mesenchymal marker fsp1. However, the results of this study and their interpretation are under debate. Here, we combine the lineage-tracing reporter with our real-time EMT-state reporter and show that the fsp1-based EMT lineage-tracing reporter does not mark all disseminating mesenchymal cells with metastatic potential. Our findings demonstrate that fsp1-mediated lineage tracing does not allow any conclusions about the requirement of EMT for metastasis. Instead our data are fully consistent with previous reports that EMT is not a binary phenomenon but rather a spectrum of cellular states.
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